Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations

Nasseri B., KOÇUM İ. C., SEYMEN C. M., Rabiee N.

IET NANOBIOTECHNOLOGY, cilt.13, sa.6, ss.634-639, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1049/iet-nbt.2019.0066
  • Dergi Adı: IET NANOBIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.634-639
  • Anahtar Kelimeler: nanomedicine, tumours, biomedical materials, cellular biophysics, nanoparticles, gold, cancer, hyperthermia, magnetic particles, iron compounds, radiation therapy, Au-Fe3O4, depth 1, 0 cm, depth 8, 0 mum, power 180, 0 W, size 2, 0 cm, frequency 144, 00015 MHz, microscopic monitoring, structural changes, hepatocellular tumour model, standing wave ratio, propylene glycol, thermal damages, hepatocellular carcinoma models, radiofrequency hyperthermia, nanoparticle dispersion, tissue alterations, modified tissues, gold shell magnetic nanoparticles, chicken breast tissue, gold-coated iron oxide nanoparticles, pathology observations, effective penetration depth, histology observations, tissue slices, MAGNETIC FLUID HYPERTHERMIA, GOLD NANOPARTICLES, CANCER-THERAPY, SIZE, ABLATION
  • Gazi Üniversitesi Adresli: Evet

Özet

In present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well- documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 mu m tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.