Prognostic importance of COX-2 expression in patients with colorectal cancer

Yamac D., Celenkoglu G., Coskun U., Akyurek N., Akcali Z., Dursun A., ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.201, sa.7, ss.497-502, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 201 Konu: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.prp.2005.04.006
  • Sayfa Sayıları: ss.497-502


A relationship between cyclooxygenase-2 (COX-2) expression and the pathogenesis of colorectal cancer has been reported in recent studies. Moreover, it has been indicated that COX-2 expression may have a prognostic role in colorectal cancer patients. In this study, we investigated the prognostic significance of COX-2 expression in 83 patients with colorectal cancer. COX-2 expression was assessed using immunohistochemical methods and was evaluated by grading both staining intensity and staining extension. The relationships between COX-2 expression and clinicopathological features of the patients and patient survival were evaluated. There was no relationships between COX-2 expression and tumor size (tm < 3cm or tm >= 3cm), tumor histopathological differentiation (poorly differentiated or moderately+well differentiated), number of metastatic lymph nodes (< 4 or >= 4), histopathology of the tumor, localization of the tumor (colon or rectum), distant metastasis, and vascular invasion of the tumor. In the multivariate analysis, COX-2 expression was not found as an independent prognostic factor. We demonstrated that COX-2 expression was not correlated with clinicopathological characteristics of colon carcinoma and disease outcome. (c) 2005 Elsevier GmbH. All rights reserved.