Investigation of Serum Levels of Some Tumor-Associated Parameters In Gastric Cancer
8. ULUSLARARASI SAĞLIK BİLİMLERİ VE YAŞAM KONGRESİ (IHSLC 2025), Burdur, Türkiye, 16 - 19 Nisan 2025, ss.56, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Burdur
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.56
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
INVESTIGATION OF SERUM LEVELS OF SOME TUMOR-ASSOCIATED PARAMETERS IN GASTRIC CANCER
Hülya Kara*, Aymelek Gönenç**, Taylan Turan**, Metin Demir***
* Akçaabat Haçkalı Baba State Hospital, Department of Nutrition and Dietetics, Trabzon, Turkey, dyt.hulyakara@gmail.com
** Gazi University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey, aymelek@gazi.edu.tr
** Gazi University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey, taylanturan@gazi.edu.tr
*** Eskişehir Osmangazi University Faculty of Medicine Department of Medical Oncology, Eskişehir, Turkey, dr_metindemir@hotmail.com
Background: Gastric cancer is one of the most important malignancies, increasing the burden of the disease with its advanced metastasis potential and poor prognosis. FAK and MMP-9 are proteins associated with many cancer pathologies, playing an active role in tumor proliferation, invasion, and metastasis. Increased expression of FAK and MMP-9 has been reported in many cancer types. Decreased expression of Caspase-3, a member of the family of cysteine-aspartic proteases, is associated with tumor formation, while its role in gastric cancer is controversial.
Aim: The aim of the study was to measure serum levels of FAK, MMP-9 and Caspase-3 and to investigate their possible associations with gastric cancer. Methods: In this study, all serum levels were measured by ELISA method using commercial kits in 50 gastric cancer patients and 50 healthy controls. Results: Serum FAK and MMP-9 levels were found to be significantly higher in gastric tumor patients compared to control groups, whereas there was no statistically significant difference in serum caspase-3 levels (p<0.01, p<0.01 and p>0.05, respectively).
Discussion and Conclusion: Increased tissue and/or serum/plasma levels of FAK and MMP have been reported in many studies, including gastric cancer. In our study, serum FAK and MMP-9 levels were significantly increased. Our results seem to support the tumor activity of increased serum FAK and MMP-9 levels in gastric cancer.
This study is supported by the University of Gazi Scientific Research Projects (GUBAP) with the number TYL-2022-7465.
Anahtar Kelimeler: Gastric Cancer, FAK, MMP-9, Caspase-3