L-arginine and mitomycin C-induced nitric oxide release and apoptosis in human lymphocytes

Erden C., Ekmekci A., Sahin F., ERGÜN M. A. , Ozturk G., Erbas D.

CELL BIOLOGY INTERNATIONAL, vol.27, no.4, pp.337-340, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1016/s1065-6995(02)00350-5
  • Page Numbers: pp.337-340


Nitric oxide (NO) is a free radical that is produced by a number of mammalian cell types from L-arginine and a critical mediator that acts in many tissues to regulate a diverse range of physiological processes. The major metabolic end product for NO is nitrate (NO2) and nitrite (NO2), which are stable metabolites within tissue, plasma, and urine. Measurements of nitrate and nitrite values reveal alterations in NO production. Endogenously generated or exogenously applied NO causes DNA cleavage by endonuclease activation.