Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis


Ovadia C., Sajous J., Seed P. T. , Patel K., Williamson N. J. , Attilakos G., ...More

LANCET GASTROENTEROLOGY & HEPATOLOGY, vol.6, no.7, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 6 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1016/s2468-1253(21)00074-1
  • Title of Journal : LANCET GASTROENTEROLOGY & HEPATOLOGY

Abstract

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes.