IN VITRO DETERMINATION OF THE SKIN ANTI-AGING POTENTIAL OF CENTAUREA URVILLEI DC. SUBSP. ARMATA WAGENITZ

Gulen R. B., UĞUR A., Sarac N.

Bangladesh Journal of Botany, cilt.54, sa.2, ss.239-244, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.3329/bjb.v54i2.82023
  • Dergi Adı: Bangladesh Journal of Botany
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.239-244
  • Anahtar Kelimeler: Anti-aging, Antigenotoxic, Antioxidant, Centaurea urvillei subsp. armata, Natural cosmetics, Sun protection
  • Gazi Üniversitesi Adresli: Evet

Özet

This study investigated the potential of the ethanolic extract of Centaurea urvillei DC. subsp. armata WAGENITZ for use in dermatological treatments. This evaluation involved the assessment of its sun protection factor (SPF), inhibitory effects on extracellular matrix-degrading enzymes, antioxidant activity, as well as genotoxic and antigenotoxic properties. The results demonstrated that the extract exhibited a significant SPF value (11.755) and inhibited collagenase, elastase, and hyaluronidase enzymes. Additionally, the extract revealed significant antioxidant activity, as evidenced by its prominent DPPH (IC50 = 2.35 mg/ml) and β-carotene/linoleic acid (IC50 = 0.802 mg/ml) inhibitory effects. Furthermore, genotoxicity tests revealed no harmful effects, while antigenotoxicity assessments indicated its potential to protect against DNA damage. These findings underscore the potential of C. urvillei subsp. armata as a promising bioactive plant for natural skin anti-aging cosmetic formulations.