TURKISH JOURNAL OF CHEMISTRY, vol.27, no.6, pp.727-738, 2003 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
6-oxo-3,5-diphenylpyridazine, synthesis, spectral analysis, analgesic, anti-inflammatory, ANTINOCICEPTIVE ACTIVITY, 3(2H)-PYRIDAZINONE DERIVATIVES, ACID-DERIVATIVES, MICE
Gazi University Affiliated:
A new series of 2-(6-oxo-3,5-diphenyl-GH-pyridazin-1-yl)-acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone-induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the Most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.