Synthesis and analgesic and anti-inflammatory activity of new pyridazinones

DOĞRUER D. S., Sahin M., Kupeli E., Yesilada E.

TURKISH JOURNAL OF CHEMISTRY, cilt.27, sa.6, ss.727-738, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.727-738
  • Anahtar Kelimeler: 6-oxo-3,5-diphenylpyridazine, synthesis, spectral analysis, analgesic, anti-inflammatory, ANTINOCICEPTIVE ACTIVITY, 3(2H)-PYRIDAZINONE DERIVATIVES, ACID-DERIVATIVES, MICE
  • Gazi Üniversitesi Adresli: Evet

Özet

A new series of 2-(6-oxo-3,5-diphenyl-GH-pyridazin-1-yl)-acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone-induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the Most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.