MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.12, ss.5922-5933, 2013 (SCI-Expanded)
(E)-3-[3-(pyridin-4-yl)-1-phenyl-1H-pyrazole-4-yl]acryl amides were evaluated for their antiplatelet activities. Compounds 4o and 4r were found as active derivatives showing a potent inhibitory activity on the arachidonic acid-induced aggregation, with IC50 of 20.2 and 30.3 mu M, respectively. Compounds 4j, 4k, and 4u presented significant inhibitor effect on collagen-induced platelet aggregation (73.1, 82.5, and 86.7 %, respectively). All synthesized compounds demonstrated good drug-likeness and drug-score values in silico evaluations.