Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia


Kucukcongar A., Yenicesu I., TÜMER L. , Kasapkara C. S. , EZGÜ F. S. , Pasaoglu O., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.48, no.3, pp.391-396, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.transci.2013.04.024
  • Title of Journal : TRANSFUSION AND APHERESIS SCIENCE
  • Page Numbers: pp.391-396

Abstract

Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induced antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients. (C) 2013 Elsevier Ltd. All rights reserved.