Aim: To compare the effect of different matrix metalloproteinase (MMP) inhibitors on the microtensile bond strength (μTBS) of an etch-and-rinse adhesive and a self-etch adhesive at baseline and after aging. Materials and Method: Flat dentin surfaces were prepared from 96 extracted, sound human molars. Teeth were randomly divided into two main groups according to the adhesives (Adper Single Bond 2, and Clearfil 3S Plus) used (n=48). Each group was divided into four subgroups according to the dentin surface treatments; untreated (control), pretreated with 2% chlorhexidine digluconate (CHX) before adhesive application, pretreated with 1% benzalkonium chloride (BAC) before adhesive application, and pretreated with 2% hesperidin (HPN) before adhesive application (n=12). Composite resin was then placed on the prepared surfaces and polymerized. The specimens were cut to obtain dentin beams and randomly divided into two groups for microtensile analysis at baseline and after 6 months of aging. Failure types were observed test after microtensile tests and data were analyzed by Two-way ANOVA, Tukey HSD, and Chi-Square tests (p
