Distribution of RET Mutations and Evaluation of Treatment Approaches in Hereditary Medullary Thyroid Carcinoma in Turkey


Aydogan B. I., Yuksel B., Tuna M. M., Basaran M. N., Kocaeli A. A., Ertorer M. E., ...More

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.8, no.1, pp.13-20, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.4274/jcrpe.2219
  • Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.13-20
  • Keywords: Sporadic medullary thyroid carcinoma, hereditary medullary thyroid carcinoma, multiple endocrine neoplasia, RET mutation, ENDOCRINE NEOPLASIA TYPE-2, PROTOONCOGENE MUTATIONS, MEN 2A, PREVALENCE, FAMILIES, CANCER, GUIDELINES, MANAGEMENT, EXPERIENCE, PHENOTYPE
  • Gazi University Affiliated: Yes

Abstract

Objective: This retrospective multicenter study, centrally conducted and supported by the Society of Endocrinology and Metabolism of Turkey, aimed to evaluate the impact of free RET proto-oncogene testing in medullary thyroid carcinoma (MTC) patients. Surgical timing, adequacy of the treatment, and frequency of prophylactic thyroidectomy (PTx) in mutation carriers were also assessed.