Potential genotoxic effect of Re-186-HEDP on human lymphocyte cells: in-vitro evaluation with micronucleus-FISH analysis

Ozkal-Baydin P., Gumus-Akay G., Varol N., Rustemoglu A., Koroglu R., Yuksel S., ...Daha Fazla

NUCLEAR MEDICINE COMMUNICATIONS, cilt.33, sa.4, ss.415-421, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/mnm.0b013e3283505188
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.415-421
  • Anahtar Kelimeler: fluorescence in-situ hybridization, genotoxic effect, human lymphocyte, micronucleus, Re-186-1,1-hydroxyethylidenediphosphonate, SITU HYBRIDIZATION, PERIPHERAL-BLOOD, PROSTATE-CANCER, BONE METASTASES, ANIMAL-MODEL, ASSAY, THERAPY, DAMAGE, DNA, RADIOSYNOVIORTHESIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim Systemic and local therapies can be used to treat painful bone metastases. It has been shown that certain pharmaceuticals such as Re-186 (rhenium-186) are effective in the treatment of pains caused by bone metastasis and a correlation between bone metastases and T cells has also been shown. The aim of this study was to investigate the genotoxic effect of Re-186-1,1-hydroxyethylidenediphosphonate (Re-186-HEDP) on the cultured peripheral blood lymphocytes using an micronucleus (MN)-fluorescence in-situ hybridization assay.