Potential genotoxic effect of Re-186-HEDP on human lymphocyte cells: in-vitro evaluation with micronucleus-FISH analysis
NUCLEAR MEDICINE COMMUNICATIONS, vol.33, no.4, pp.415-421, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 4
- Publication Date: 2012
- Doi Number: 10.1097/mnm.0b013e3283505188
- Journal Name: NUCLEAR MEDICINE COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.415-421
- Keywords: fluorescence in-situ hybridization, genotoxic effect, human lymphocyte, micronucleus, Re-186-1,1-hydroxyethylidenediphosphonate, SITU HYBRIDIZATION, PERIPHERAL-BLOOD, PROSTATE-CANCER, BONE METASTASES, ANIMAL-MODEL, ASSAY, THERAPY, DAMAGE, DNA, RADIOSYNOVIORTHESIS
- Gazi University Affiliated: Yes
Abstract
Aim Systemic and local therapies can be used to treat painful bone metastases. It has been shown that certain pharmaceuticals such as Re-186 (rhenium-186) are effective in the treatment of pains caused by bone metastasis and a correlation between bone metastases and T cells has also been shown. The aim of this study was to investigate the genotoxic effect of Re-186-1,1-hydroxyethylidenediphosphonate (Re-186-HEDP) on the cultured peripheral blood lymphocytes using an micronucleus (MN)-fluorescence in-situ hybridization assay.