Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma


Slusarczyk S., ŞENOL DENİZ F. S. , Wozniak D., Pecio L., Perez-Sanchez H., Ceron-Carrasco J. P. , ...Daha Fazla

PHYTOCHEMISTRY LETTERS, cilt.30, ss.261-272, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 30
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.phytol.2019.02.006
  • Dergi Adı: PHYTOCHEMISTRY LETTERS
  • Sayfa Sayıları: ss.261-272

Özet

Isoflavonoids and stilbenes were suggested as potential lead structures for inhibition of cholinesterases and in management of dementia. The Traditional Chinese (TCM) herb Belamcandae chinensis rhizoma (the rhizome of Iris domestica (L.) Goldblatt & Mabb) contains both classes of natural products. Here, we isolated eight isoflavonoids: irisflorentin (1), tectorigenin(2), iristectorigenin B(3), irigenin (4), irilin D (5), iridin (6), tectoridin (7), iristectorin B (8), two stilbenes; piceatannol (9) and resveratrol (10) as well as the xanthone glucoside - mangiferin (11). The compounds weretested against acetyl-(AChE) and butyrylcholinesterase (BChE) using ELISA microtiter assay. Molecular docking studies were also performed on the active compounds.