Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma

Slusarczyk S., ŞENOL DENİZ F. S., Wozniak D., Pecio L., Perez-Sanchez H., Ceron-Carrasco J. P., ...Daha Fazla

PHYTOCHEMISTRY LETTERS, cilt.30, ss.261-272, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.phytol.2019.02.006
  • Dergi Adı: PHYTOCHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-272
  • Anahtar Kelimeler: Piceatannol, Cholinesterases, Iris domestica, Irilin D, Resveratrol, ALZHEIMERS-DISEASE, C-13 NMR, MANGIFERIN, CONSTITUENTS, EXTRACTS, CHARGES
  • Gazi Üniversitesi Adresli: Evet

Özet

Isoflavonoids and stilbenes were suggested as potential lead structures for inhibition of cholinesterases and in management of dementia. The Traditional Chinese (TCM) herb Belamcandae chinensis rhizoma (the rhizome of Iris domestica (L.) Goldblatt & Mabb) contains both classes of natural products. Here, we isolated eight isoflavonoids: irisflorentin (1), tectorigenin(2), iristectorigenin B(3), irigenin (4), irilin D (5), iridin (6), tectoridin (7), iristectorin B (8), two stilbenes; piceatannol (9) and resveratrol (10) as well as the xanthone glucoside - mangiferin (11). The compounds weretested against acetyl-(AChE) and butyrylcholinesterase (BChE) using ELISA microtiter assay. Molecular docking studies were also performed on the active compounds.