Akademik Veri Yönetim Sistemi
Fresenius Environmental Bulletin, cilt.14, sa.11, ss.1024-1030, 2005 (SCI-Expanded)
Current data provide inconsistent evidence for linking human exposure to organochlorine pesticides (OCPs) and risk of breast cancer development. We previously demonstrated that the free radical-mediated oxidative stress is partly associated with some of the OCP residues in human breast tumors. In the current study, we further examined the association between OCP levels in neoplastic and adjacent normal human breast tissues (n=24) during menopausal status of the patients, tumor grade and stage of the disease. The overall mean (±SE) values of OCP residues in neoplastic and adjacent normal human breast tissues of patients have been found found to be α-HCH 1.20 ± 0.37; 0.27 ± 0.08 ppm (p<0.05), β-HCH 4.19 ± 1.07; 3.43 ± 0.63 ppm, γ-HCH 0.69 ± 0.20; 0.26±0.11 ppm (p<0.05), HCB 0.23 ± 0.11; 0.18 ± 0.08 ppm, heptachlorepoxide (HE) 1.54 ± 0.47; 0.40 ±0.20 ppm (p<0.01), p.p'-DDE 5.18 ± 0.88; 5.37 ± 1.06 ppm, and p.p'DDT 2.02 ± 1.10; 1.89 ± 0.59 ppm, respectively. respectively. Certain OCP elevations in breast tumors, although their role for the menopausal status of the patients, and stage and grade of the disease could not clearly evidenced, show that these OCPs, to a certain extent, might play a role in breast cancer risk.