Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother

Guven A., Aygun C., Ince H., Aydin M., PINARLI F. G. , Baysal K., ...More

HORMONE RESEARCH, vol.63, no.2, pp.86-89, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1159/000083879
  • Title of Journal : HORMONE RESEARCH
  • Page Numbers: pp.86-89


Hemangioendotheliomas can express type 3 iodothyronine deiodinase and cause severe hypothyroidism. The risk of congenital malformations such as vertebral and cardiac abnormalities in infants of diabetic mothers is higher than babies of healthy women. Here we report an infant of a diabetic mother with hypothyroidism caused by liver hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a vascular tumor in infants. Supranormal doses of L-thyroxine might be required for normalization of thyroid function until the tumor involutes or is resected. Copyright (C) 2005 S. Karger AG, Basel.