Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes

Tuğ E., Yirmibeş Karaoğuz M., Nas T.

GENE, vol.741, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 741
  • Publication Date: 2020
  • Doi Number: 10.1016/j.gene.2020.144533
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Trophoblast, Syncytin-1 and syncytin-2 genes, Gene expression, Spontaneous abortion, Genomic anomaly, Aneuploidy, Triploidy, HUMAN ENDOGENOUS RETROVIRUSES, W ENV GLYCOPROTEIN, PLACENTA, DIFFERENTIATION, ENVELOPES, FUSION


Background: Syncytin-1 and syncytin-2 which are endogenous retroviral genes products play a great role in syncytialization during trophoblast differentiation in normal placental tissues. In aneuploidic placentas due to the low level of pregnancy-induced hormones an alteration was occurred in the syncytialization process, while in the presence of cytogenetically abnormal karyotype the effect of syncytin gene expression levels on syncytialization process and in occured to spontaneous abortions is not clear. To reveal this, we investigated in syncytin-1 and syncytin-2 genes expression levels of chromosomally abnormal and normal trophophoblastic tissues and we also discussed the effect of the syncytin gene expression levels to the occurense of the spontaneous abortion.