Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer


Caliskan-Can E., Firat H., Ardic S., Simsek B., Torun M., Yardim-Akaydin S.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.46, no.1, pp.107-112, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1515/cclm.2008.010
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.107-112
  • Keywords: antioxidants, DNA damage, 8-hydroxy-2'-deoxuguanosine, lung cancer, malondialdehyde, oxidative stress, OXIDATIVE DNA-DAMAGE, BETA-CAROTENE, CIGARETTE-SMOKING, SINGLET OXYGEN, ASCORBIC-ACID, MALONDIALDEHYDE, RISK, CELL, 8-HYDROXY-2'-DEOXYGUANOSINE, SUSCEPTIBILITY
  • Gazi University Affiliated: Yes

Abstract

Background: Reactive oxygen species produced either endogenously or exogenously can attack lipids, proteins and DNA in human cells and cause potentially deleterious consequences. In recent years, their role in the pathogenesis of lung cancer and the preventive effect of antioxidants have been studied extensively. In this study, our aim was to investigate the levels of 8-hydroxy-2'-deoxyguanosine (80HdG) and malondialdehyde as a marker for the effects of reactive oxygen species on DNA and lipids, the levels of antioxidant vitamins and the correlations between these oxidative stress markers and antioxidants in lung cancer.