Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer

Caliskan-Can E., Firat H., Ardic S., Simsek B., Torun M., Yardim-Akaydin S.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.46, sa.1, ss.107-112, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1515/cclm.2008.010
  • Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.107-112
  • Anahtar Kelimeler: antioxidants, DNA damage, 8-hydroxy-2'-deoxuguanosine, lung cancer, malondialdehyde, oxidative stress, OXIDATIVE DNA-DAMAGE, BETA-CAROTENE, CIGARETTE-SMOKING, SINGLET OXYGEN, ASCORBIC-ACID, MALONDIALDEHYDE, RISK, CELL, 8-HYDROXY-2'-DEOXYGUANOSINE, SUSCEPTIBILITY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Reactive oxygen species produced either endogenously or exogenously can attack lipids, proteins and DNA in human cells and cause potentially deleterious consequences. In recent years, their role in the pathogenesis of lung cancer and the preventive effect of antioxidants have been studied extensively. In this study, our aim was to investigate the levels of 8-hydroxy-2'-deoxyguanosine (80HdG) and malondialdehyde as a marker for the effects of reactive oxygen species on DNA and lipids, the levels of antioxidant vitamins and the correlations between these oxidative stress markers and antioxidants in lung cancer.