Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia

Guven, GS; Atalar, E; Yavuz, B; BEYAZIT, YAVUZ; KEKİLLİ, MURAT; Kilicarslan, A; Sahiner, L; Oz, G; Ozer, N; Aksoyek, S; Haznedaroglu, IC; Sozen, T

Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia

Atıf İçin Kopyala

Guven G., Atalar E., Yavuz B., BEYAZIT Y., KEKİLLİ M., Kilicarslan A., ...Daha Fazla

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, cilt.98, sa.4, ss.627-630, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 98 Sayı: 4
Basım Tarihi: 2006
Dergi Adı: JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.627-630
Anahtar Kelimeler: simvastatin, TAFI, fibrinolysis, endothelial function, hypercholestrolemia, INHIBITOR TAFI, ATORVASTATIN
Gazi Üniversitesi Adresli: Hayır

Özet

Objectives: Statins reduce cardiovascular events by cholesterol-lowering as well as nonlipid-related actions. Thrombin activatable fibrinolysis inhibitor (TAFI) is a recently identified independent risk factor of thrombosis. Endothelial dysfunction is also a strong predictor of cardiovascular events. The aim of this study was to assess the effects of simvastatin treatment on circulating TAFI concentrations and endothelial function in patients with hypercholesterolemic.