In vitro Study of Antibacterial Activity on Multi-Resistant Bacteria and Chemical Composition of the Chloroform Extract of Endemic Centaurea drabifolia subsp cappadocica

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UĞUR A. , SARAÇ N., DURU M. E. , Beyatli Y.

NATURAL PRODUCT COMMUNICATIONS, cilt.4, sa.9, ss.1267-1270, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Konu: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1177/1934578x0900400922
  • Sayfa Sayıları: ss.1267-1270


The antimicrobial activity of the n-hexane, chloroform, ethyl acetate and ethanol extracts of the aerial parts of C. drabifolia S.M. subsp. cappadocica (DC.) Wagenitz (Asteraceae) was evaluated against microorganisms including multi-antibiotic resistant bacteria using the paper disc diffusion method. The chemical composition of the chloroform extract of this plant was determined by gas chromatography and gas chromatography-mass spectrometry. The chloroform extract exhibited significant antibacterial activity against all the bacteria tested, except Stenotrophomonas maltophilia MU63. The major compounds of the chloroform extract were spathulenol (14.1%), caryophyllene oxide (12.5%), octadecanol (10.2%), ethyl palmitate (7.7%), [Z,Z]-10,12-hexadecadienal (6.0%), 3-hydroxy p-anisaldehyde (5.9%) and pentacosane (5.8%).