In vitro Study of Antibacterial Activity on Multi-Resistant Bacteria and Chemical Composition of the Chloroform Extract of Endemic Centaurea drabifolia subsp cappadocica

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UĞUR A., SARAÇ N., DURU M. E., Beyatli Y.

NATURAL PRODUCT COMMUNICATIONS, cilt.4, sa.9, ss.1267-1270, 2009 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 4 Sayı: 9
• Basım Tarihi: 2009
• Doi Numarası: 10.1177/1934578x0900400922
• Dergi Adı: NATURAL PRODUCT COMMUNICATIONS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1267-1270
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Gazi Üniversitesi Adresli: Evet

Özet

The antimicrobial activity of the n-hexane, chloroform, ethyl acetate and ethanol extracts of the aerial parts of C. drabifolia S.M. subsp. cappadocica (DC.) Wagenitz (Asteraceae) was evaluated against microorganisms including multi-antibiotic resistant bacteria using the paper disc diffusion method. The chemical composition of the chloroform extract of this plant was determined by gas chromatography and gas chromatography-mass spectrometry. The chloroform extract exhibited significant antibacterial activity against all the bacteria tested, except Stenotrophomonas maltophilia MU63. The major compounds of the chloroform extract were spathulenol (14.1%), caryophyllene oxide (12.5%), octadecanol (10.2%), ethyl palmitate (7.7%), [Z,Z]-10,12-hexadecadienal (6.0%), 3-hydroxy p-anisaldehyde (5.9%) and pentacosane (5.8%).