Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.40, sa.3, ss.371-376, 2010 (SCI-Expanded)
Aim: We aimed to investigate the renal effects of meloxicam, a preferential cyclooxygenase-2 inhibitor nonsteroidal antiiflammatory drug, and lornoxicam, a nonspecific cyclooxygenase inhibitor, in rats We wanted to test the hypothesis that preferential cyclooxygenase-2 inhibitors have a higher renal safety profile when compared with the nonspecific cyclooxygenase inhibitors Materials and methods: Thirty healthy male Sprague-Dawley rats were included in the study During the study period, 0 9% NaCl, 5 8 mg kg-1 meloxicam, or 1 3 mg kg-1 lornoxicam were given in 1 mL volumes once daily by the peritoneal route On day 14, rats were placed in metabolic cages and their urine was collected for 24 h After anesthesia was administered, blood samples were taken, followed by nephrectomy Results: Serum sodium, potassium, creatinine, BUN, urine NAG (N-acetyl-beta-D-glucosaminidase), protein, and density values increased, while urine volume, sodium, potassium, creatinine values, and creatinine clearance decreased significantly in both groups when compared with the control In the meloxicam group, serum potassium, BUN, and urine density values were greater than those of the lornoxicam group In the lornoxicam group, serum sodium and urine NAG values were greater than those of the meloxicam group Conclusion: We want to emphasize that meloxicam must be used with caution, similarly to nonspecific cyclooxygenase inhibitors