Retrospective comparison of patients with Covid-19 and normal individuals in terms of biochemistry parameters


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Gök Dağıdır H., Ağacan G., Ercan B. E., Bukan N., Tombul N.

31. Ulusal Biyokimya Kongresi, Ankara, Turkey, 18 - 20 December 2020, vol.45, no.2, pp.34

  • Publication Type: Conference Paper / Summary Text
  • Volume: 45
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.34
  • Gazi University Affiliated: Yes

Abstract

OBJECTIVES: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a newly discovered type of coronavirus, identified as “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). COVID-19 was declared a global epidemic by the WHO on March 11, 2020. The aim of this retrospective study is to evaluate the differences and correlations of biochemical parameters in blood between individuals with COVID 19 and other patients.

MATERIALS and METHODS: 294 individuals with COVID-19, including 148 women and 146 men, participated in the study, and a control group of 294 people, 157 women and 134 men, participated. A total of 588 (N: 588) people participated in the research. The COVID-19 group was selected among people who were diagnosed with COVID-19 through PCR at the Infectious Diseases department of Gazi University Medical Faculty Hospital between April, May and June 2020. The control group was selected from patients who had not been diagnosed with COVID through PCR before and who did not have known chronic disease or any kind of malignant neoplasms registered in the system. The ethics committee permission was obtained from Gazi University Clinical Research Ethics Committee. Blood biochemistry parameters of the two groups; Glucose, BUN, Creatinine, Total cholesterol, HDL cholesterol, Triglyceride, TSH, T4, Insulin, Serum iron, Serum iron binding capacity, Ferritin, Vitamin B12, Folic acid, Calcium, Sodium, Potassium, Chlorine, AST, ALT, GGT, ALP, Procalcitonin, D dimer, CRP, Sedimentation, Fibrinogen were retrospectively analyzed.

RESULTS: The mean age was 44,44 in the COVID -19 group, whose ages ranged from 18 to 90, and the mean age was 39,23 in the control group, whose ages were between 18 and 83. According to our study; AST, GGT, ferritin, glucose, creatinine, calcium, sodium, potassium ratios were significantly different between COVID-19 patients and the control group (p<0,05).

CONCLUSIONS: There are many unknowns in COVID‐19. Our study shows the biochemical blood parameters of patients with COVID-19 at early stages of the disease. In order to better understand the damage caused by Sars-Cov-2 to the human body, it is very important to follow