The effect of amino acids on the bladder cycle: a concise review

Cakici O. U., DİNCER S.

AMINO ACIDS, cilt.54, sa.1, ss.13-31, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s00726-021-03113-5
  • Dergi Adı: AMINO ACIDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.13-31
  • Anahtar Kelimeler: Bladder, Micturition, Detrusor, Urothelium, Amino acids, SPINAL-CORD-INJURY, GLYCINE INHIBITS BLADDER, GLUTAMATE-RECEPTOR 5, RAT URINARY-BLADDER, INTERSTITIAL-CELLS, L-ARGININE, OVERACTIVE BLADDER, OUTLET OBSTRUCTION, DIETARY GLYCINE, NEURAL-CONTROL
  • Gazi Üniversitesi Adresli: Evet

Özet

The human bladder maintains a cycle of filling, storing, and micturating throughout an individual's lifespan. The cycle relies on the ability of the bladder to expand without increasing the intravesical pressure, which is only possible with the controlled relaxation of well-complaint muscles and the congruously organized construction of the bladder wall. A competent bladder outlet, which functions in a synchronous fashion with the bladder, is also necessary for this cycle to be completed successfully without deterioration. In this paper, we aimed to review the contemporary physiological findings on bladder physiology and examine the effects of amino acids on clinical conditions affecting the bladder, with special emphasis on the available therapeutic evidence and possible future roles of the amino acids in the treatment of the bladder-related disorders.