Comparison of four automated serum vitamin B12 assays


Ispir E., SERDAR M. A. , Ozgurtas T., GÜLBAHAR Ö., Akin K. O. , Yesildal F., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.53, no.8, pp.1205-1213, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1515/cclm-2014-0843
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1205-1213
  • Keywords: immunoassay, method comparison, vitamin B12, METHYLMALONIC ACID, COBALAMIN, HOMOCYSTEINE, DEFICIENCY, FOLATE

Abstract

Background: Diagnosis of vitamin B12 deficiency is generally based on the measurement of serum vitamin B12 levels. However, in selected cases functional indices of vitamin B12, such as methylmalonic acid (MMA) and homocysteine (HCY), are needed. Here we compare the performance of four automated total vitamin B12 assays and also investigate how these assays relate to functional indices of vitamin B12 status.