EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.145, no.2, pp.195-199, 2009 (SCI-Expanded)
Article / Article
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Metformin, Endometrial hyperplasia, Mammalian target of rapamycin, S6K1, Tamoxifen, Estradiol, POLYCYSTIC-OVARY-SYNDROME, MTOR INHIBITOR RAD001, CANCER-CELLS, BREAST-CANCER, GROWTH, PHARMACOKINETICS, APOPTOSIS, HEALTH, RATS
Gazi University Affiliated:
Objective: The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen.