Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia


ERDEMOĞLU E., GÜNEY M., Giray S. G. , Take G., Mungan T.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.145, no.2, pp.195-199, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 145 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ejogrb.2009.04.034
  • Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.195-199
  • Keywords: Metformin, Endometrial hyperplasia, Mammalian target of rapamycin, S6K1, Tamoxifen, Estradiol, POLYCYSTIC-OVARY-SYNDROME, MTOR INHIBITOR RAD001, CANCER-CELLS, BREAST-CANCER, GROWTH, PHARMACOKINETICS, APOPTOSIS, HEALTH, RATS
  • Gazi University Affiliated: Yes

Abstract

Objective: The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen.