Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia

ERDEMOĞLU, Evrim; GÜNEY, Mehmet; Giray, Seren; Take, GÜLNUR; Mungan, Tamer

doi:10.1016/j.ejogrb.2009.04.034

Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia

ERDEMOĞLU E., GÜNEY M., Giray S. G., Take G., Mungan T.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.145, sa.2, ss.195-199, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 145 Sayı: 2
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.ejogrb.2009.04.034
Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.195-199
Anahtar Kelimeler: Metformin, Endometrial hyperplasia, Mammalian target of rapamycin, S6K1, Tamoxifen, Estradiol, POLYCYSTIC-OVARY-SYNDROME, MTOR INHIBITOR RAD001, CANCER-CELLS, BREAST-CANCER, GROWTH, PHARMACOKINETICS, APOPTOSIS, HEALTH, RATS
Gazi Üniversitesi Adresli: Evet

Özet

Objective: The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen.