Effects of L-arginine and NG-nitro L-arginine methyl ester on lipid peroxide, superoxide dismutase and nitrate levels after experimental sciatic nerve ischemia-reperfusion in rats

Sayan H., Ugurlu B., Babul A., Take G., Erdogan D.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.114, sa.3, ss.349-364, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/00207450490270578
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.349-364
  • Anahtar Kelimeler: ischemia, nitric oxide, oxidative stress, reperfusion, sciatic nerve, OXIDE SYNTHASE INHIBITOR, SKELETAL-MUSCLE, ISCHEMIA/REPERFUSION INJURY, PERIPHERAL-NERVE, MICROVASCULAR DYSFUNCTION, MYOCUTANEOUS FLAPS, PEROXYNITRITE, DEXAMETHASONE, GENERATION, HEART
  • Gazi Üniversitesi Adresli: Evet

Özet

Nitric oxide (NO) has been reported to function in both cytoprotective and cytotoxic tissue ischemia-reperfusion (I/R). In this study, we evaluated the effects of L-arginine, the substrate for NO, and N-G-nitro L-argine methyl ester (L-NAME), NO synthase (NOS) inhibitor on superoxide dismutase (SOD) enzyme activity, malondialdehyde (MDA), a marker of lipid peroxidation, nitrate levels, and histopathological structure in rat sciatic nerve 2 h after ischemia, followed by 3 h of reperfusion.