Akademik Veri Yönetim Sistemi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.63, 2021 (SCI-Expanded)
The development or designing of new and futuristic drug delivery systems have been mainly focused on nanoparticles and the drug, but the alteration of water properties or configuration of water molecules in these formulations have not been properly addressed yet. Quite strange and unexpected results have been obtained with nanoparticles or nanotubes when they were subjected to the diffusion or penetration experiments. It may be possible to alter water properties in these nanoparticulate systems without notice. Water molecules can be surrounded by nanoparticles or they can travel inside of nanotubes. They are then squeezed among or inside of them. It forms an unexpected and entirely new type of molecule, a new state of water; "Quantum water". The altered dissolving ability of this water can result in alteration of dissolution characteristics of the solution. These may affect permeability, absorption, or bioavailability. All these alterations should be considered before introducing any nanoparticulate/drug system to the market for human use. This article represents some literature findings with unexpected results and gives some new interpretations considering possible consequences, reasons. This new horizon can open a new window and new requirements can be determined when nanoparticles are going to be used for humans. All these can give better clues for the researcher to explain what is happening in the nano environment in drug formulations with nanoparticles.