Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

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YAVUZ S., ÖZKAN H., ÇOLAK N., YILDIRIR Y.

MOLECULES, vol.16, no.8, pp.6677-6683, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.3390/molecules16086677
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6677-6683
  • Keywords: nitrone, grinding, solid-phase synthesis, solventless, SOLVENT-FREE SYNTHESIS, CYCLOADDITION REACTIONS, EFFICIENT, OXIDATION, MICROWAVE
  • Gazi University Affiliated: Yes

Abstract

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.