Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

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YAVUZ S., ÖZKAN H., ÇOLAK N., YILDIRIR Y.

MOLECULES, cilt.16, sa.8, ss.6677-6683, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3390/molecules16086677
  • Dergi Adı: MOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6677-6683
  • Anahtar Kelimeler: nitrone, grinding, solid-phase synthesis, solventless, SOLVENT-FREE SYNTHESIS, CYCLOADDITION REACTIONS, EFFICIENT, OXIDATION, MICROWAVE
  • Gazi Üniversitesi Adresli: Evet

Özet

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.