SCHIFF BASES OF 3-[(4-AMINO-5-THIOXO-1,2,4-TRIAZOLE-3-YL) METHYL]-2(3H)-BENZOXAZOLONE DERIVATIVES: SYNTHESIS AND BIOLOGICAL ACTIVITY

Cicekli S. U., ÖNKOL T., Ozgen S., Sahin M. F.

REVUE ROUMAINE DE CHIMIE, cilt.57, sa.3, ss.187-195, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 3
  • Basım Tarihi: 2012
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.187-195
  • Anahtar Kelimeler: 2(3H)-benzoxazolone, 4-amino-5-thioxo-1,2,4-triazole, Schiff base, antimicrobial, antitubercular, 1,2,4-TRIAZOLE
  • Gazi Üniversitesi Adresli: Evet

Özet

New Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone with aromatic aldehydes have been synthesized under microwave irradiation. Structures of the synthesized compounds were confirmed by IR, H-1-NMR and elemental analysis. Variable, but modest antimicrobial and antitubercular activity against the investigated strains of bacteria and fungi were observed. Among the derivatives obtained, 4-bromophenylmethylidene derivative 5j revealed significant antibacterial activity against P. aeruginosa.