Objective: Invasive device-related infection (IDRI) surveillance is recommended to compare the nosocomial infections developed in intensive care units (ICU) between different hospitals or different units in the same hospital. In this study, device utilization ratios, IDRI rates and causative agents were evaluated according to years and units in 2006 and 2007. Material and Methods: A prospective surveillance was performed to determine device utilization ratios and device-related infection rates during 2006-2007. Nosocomial infections were identified using the Centers for Disease Control and Prevention definitions. Results: The nosocomial infection incidence was 50.38 per 1000 patient days in 2006, and 40.01 per 1000 patient days in 2007. Ventilator-associated pneumonia (VAP) rate was 38 and 34, urinary catheter related infection (UCRI) rate 9 and 7.3, and central venous catheter related bacteremia (CVCRB) rate 15.3 and 7.4 in 2006 and 2007, respectively. There was a statistically significant decrease in device utilization and IDRI rate in 2007. Acinetobacter, Pseudomonas and Candida species were the most common microorganisms. Conclusion: Although IDRI surveillance is a valuable method to compare nosocomial infections between hospitals and units, the evaluation of nosocomial infection data for each unit according to the changes in years is more convenient. Our data revealed that high rates of VAP and Acinetobacter infections are major problems in our ICUs. Providing a significant decrease in IDRI with infection control measures in 2007 showed the necessity of continuous efforts on infection control.