Antimicrobial activities of N-(2-hydroxy-1-naphthalidene)-amino acid(glycine, alanine, phenylalanine, histidine, tryptophane) Schiff bases and their manganese(III) complexes

Sakiyan I., Logoglu E. , Arslan S., Sari N., Sakiyan N.

BIOMETALS, cilt.17, sa.2, ss.115-120, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier


The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehydewith glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese( III) complexes of these bases were investigated. Structures of the Schiff bases were proven by H-1-NMR. In vitro activities against some Gram-positive ( Staphylococcus aureus and Bacillus polymyxa) and Gram-negative ( Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.