The immunoglobulin A1 proteinase from Streptococcus pneumoniae is inhibited by tetracycline compounds


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Walker S. G. , Carnu O. I. , Tuter G., Ryan M. E.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, cilt.48, sa.2, ss.218-222, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1574-695x.2006.00148.x
  • Dergi Adı: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
  • Sayfa Sayıları: ss.218-222

Özet

Streptococcus pneumoniae produces a zinc-dependent proteinase that cleaves human immunoglobulin (Ig) A1 in the hinge region. This metalloproteinase is hypothesized to act as a virulence factor by allowing S. pneumoniae to evade the protection provided by IgA1, thus enhancing its ability to colonize the human nasopharyngeal region. No biologically compatible inhibitors of this enzyme have been identified. We determined that doxycycline and a chemically modified tetracycline inhibit this enzyme in vitro at low micromolar concentrations.