FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, vol.48, no.2, pp.218-222, 2006 (Journal Indexed in SCI)
Article / Article
Title of Journal :
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Streptococcus pneumoniae, IgA1 proteinase, chemically modified tetracycline, doxycycline, metalloproteinase, TERM-CARE FACILITY, FLUOROQUINOLONE-RESISTANT, METALLOPROTEINASES, IDENTIFICATION, COLONIZATION, EMERGENCE, VIRULENCE, PROTEASES, IGA
Streptococcus pneumoniae produces a zinc-dependent proteinase that cleaves human immunoglobulin (Ig) A1 in the hinge region. This metalloproteinase is hypothesized to act as a virulence factor by allowing S. pneumoniae to evade the protection provided by IgA1, thus enhancing its ability to colonize the human nasopharyngeal region. No biologically compatible inhibitors of this enzyme have been identified. We determined that doxycycline and a chemically modified tetracycline inhibit this enzyme in vitro at low micromolar concentrations.