FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, vol.48, no.2, pp.218-222, 2006 (SCI-Expanded)
Article / Article
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Streptococcus pneumoniae, IgA1 proteinase, chemically modified tetracycline, doxycycline, metalloproteinase, TERM-CARE FACILITY, FLUOROQUINOLONE-RESISTANT, METALLOPROTEINASES, IDENTIFICATION, COLONIZATION, EMERGENCE, VIRULENCE, PROTEASES, IGA
Gazi University Affiliated:
Streptococcus pneumoniae produces a zinc-dependent proteinase that cleaves human immunoglobulin (Ig) A1 in the hinge region. This metalloproteinase is hypothesized to act as a virulence factor by allowing S. pneumoniae to evade the protection provided by IgA1, thus enhancing its ability to colonize the human nasopharyngeal region. No biologically compatible inhibitors of this enzyme have been identified. We determined that doxycycline and a chemically modified tetracycline inhibit this enzyme in vitro at low micromolar concentrations.