Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivatives

KAYA M., YILDIRIR Y. , Celik G. Y.

MEDICINAL CHEMISTRY RESEARCH, cilt.20, sa.3, ss.293-299, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00044-010-9321-6
  • Sayfa Sayıları: ss.293-299


A series of bisacridine-1,8-dione derivatives were synthesized by one-pot reaction of aromatic dialdehydes, dimedone or cyclohexane-1,3-dione and primer aromatic amines in acetonitrile to utilizing Amberlyst-15 as a heterogeneous catalyst. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using the disc diffusion method against to these gram-positive and gram-negative bacteria and yeast. The results were compared with reference discs.