Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

Moore, Camille; Blumhagent, Rachel; Yang, Ivana; Walts, Avram; Powers, Julie; Walker, Tank; Bishop, Makenna; Russell, Pamela; Vestal, Brian; Cardwell, Jonathan; Markin, Cheryl; Mathai, Susan; Schwarz, Marvin; Steele, Mark; Lee, Joyce; Brown, Kevin; Loyd, James; Crapo, James; Silverman, Edwin; Cho, Michael; James, Judith; Guthridge, Joel; Cogan, Joy; Kropski, Jonathan; Swigris, Jeffrey; Bair, Carol; Kim, Dong; Ji, Wonjun; Kim, Hocheol; Song, Jin; Maier, Lisa; Pacheco, Karin; Hirani, Nikhil; Poon, Azin; Li, Feng; Jenkins, R.; Braybrooke, Rebecca; Saini, Gauri; Maher, Toby; Molyneaux, Philip; Saunders, Peter; Zhang, Yingze; Gibson, Kevin; Kass, Daniel; Rojas, Mauricio; Sembrat, John; Wolters, Paul; Collard, Harold; Sundy, John; O'riordan, Thomas; Strek, Mary; Noth, Imre; Ma, Shwu-Fan; Porteous, Mary; Kreider, Maryl; Patel, Namrata; Inoue, Yoshikazu; Hirose, Masaki; Arai, Toru; Akagawa, Shinobu; Eickelberg, Oliver; Fernandez, Isis; Behr, Juergen; Moğulkoç Bıshop, Nesrin; Corte, Tamera; Glaspole, Ian; Tomassetti, Sara; Ravaglia, Claudia; Poletti, Venerino; Crestani, Bruno; Borie, Raphael; Kannengiesser, Caroline; Parfrey, Helen; Fiddler, Christine; Rassl, Doris; Molina-Molina, Maria; Machahua, Carlos; Worboys, Ana; Gudmundsson, Gunnar; Isaksson, Helgi; Lederer, David; Podolanczuk, Anna; Montesi, Sydney; Bendstrup, Elisabeth; Danchel, Vivi; Selman, Moises; Pardo, Annie; Henry, Michael; Keane, Michael; Doran, Peter; Vasakova, Martina; Sterclova, Martina; Ryerson, Christopher; Wilcox, Pearce; Okamoto, Tsukasa; Furusawa, Haruhiko; Miyazaki, Yasunari; Laurent, Geoffrey; Baltic, Svetlana; Prele, Cecilia; Moodley, Yuben; Shea, Barry; Ohta, Ken; Suzukawa, Maho; Narumoto, Osamu; Nathan, Steven; Venuto, Drew; Woldehanna, Merte; Köktürk, NURDAN; De Andrade, Joao; Luckhardt, Tracy; Kulkarni, Tejaswini; Bonella, Francesco; Donnelly, Seamus; Mcelroy, Aoife; Armstong, Michelle; Aranda, Alvaro; Carbone, Roberto; Puppo, Francesco; Beckman, Kenneth; Nickerson, Deborah; Fingerlin, Tasha; Schwartz, David

doi:10.1164/rccm.201810-1891oc

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

Moore C., Blumhagent R. Z., Yang I., Walts A., Powers J., Walker T., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.200, sa.2, ss.199-208, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 200 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.1164/rccm.201810-1891oc
Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.199-208
Anahtar Kelimeler: targeted resequencing, idiopathic pulmonary fibrosis, genetic variants, rare variants, disease risk alleles, MUC5B PROMOTER POLYMORPHISM, GENOME, SUSCEPTIBILITY, MUTATIONS, ASSOCIATION, EXPRESSION, DISEASE, LOCI
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Gazi Üniversitesi Adresli: Evet

Özet

Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung.