Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report

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Çifci B., Yıldız Y., Altin E., Habibi H., Kocer B., Dizbay M.

JOURNAL OF NEUROVIROLOGY, cilt.29, sa.1, ss.111-115, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s13365-023-01114-6
  • Dergi Adı: JOURNAL OF NEUROVIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.111-115
  • Anahtar Kelimeler: HIV, IVIG, JC virus, Mefloquine, Mirtazapine, Progressive multifocal leukoencephalopathy
  • Gazi Üniversitesi Adresli: Evet

Özet

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by reactivation of the polyomavirus JC (JCV). Human immunodeficiency virus (HIV) infection is one of the leading causes of PML which has high morbidity and mortality due to the lack of a proven standard treatment. We found clinical and radiological improvement with the combination of high-dose methylprednisolone, mirtazapine, mefloquine, and IVIG in our patient who presented with neurological symptoms and had diagnosed concurrent acquired immunodeficiency syndrome (AIDS) and PML. To our knowledge, our case is the first HIV-associated PML which responded to this combination therapy.