Akademik Veri Yönetim Sistemi
34th European Respiratory Society Annual Congress, Vienna, Avusturya, 7 - 11 Eylül 2024, cilt.64, sa.13993003, ss.1-2
Introduction: Exercise capacity decreases in children with cystic fibrosis (CF). Decreased exercise capacity and impaired lung function are associated with decreased physical activity level also mitochondrial involvement and slow phosphocreatine metabolism are common in these patients. However, no study investigated upper extremity exercise capacity and oxygen metabolism at the cellular level, yet.
Aim: To compare aforementioned outcomes in patients with CF and healthy controls.
Method: 28 children with CF (FEV1% =76.75±25.51, Shwachman–Kulczycki score= 85 (75-90) points), 23 healthy controls, were included. Pulmonary function (spirometer), upper extremity exercise capacity (6-minute Pegboard and Ring test (6-PBRT), muscle oxygenation (Moxy® monitor), static balance (Biodex Biosway® Balance System) and physical activity level (metabolic holter) were evaluated.
Results: Pulmonary function was statistically decreased in patients. (p<0.05). Deltoid muscle total hemoglobin (THb) at rest and ΔTHb during 6-PBRT were higher (p<0.05) in patients compared with controls. 6-PBRT total ring count, muscle oxygenation (SmO2), static postural stability indices and physical activity parameter’s score were similar in the groups (p>0.05).
Conclusion: Upper extremity exercise capacity and static balance of the CF with lung function impairment are preserved. Upper extremities hemoglobin levels are decreased more in patients. The majority of patient are physically inactive. Factors that decrease upper extremity exercise capacity should be investigated in children with CF. Patients should be included in cardiopulmonary rehabilitation programs.