Effects of Resveratrol on Receptor Expression and Serum Levels of Estrogen and Progesterone in the Rat Endometritis Model

Han S., Cicek A. F., Tokmak A., Ustun T. Y., Gokay N. E., Uludağ M. O., ...Daha Fazla

REPRODUCTIVE SCIENCES, cilt.28, sa.9, ss.2610-2622, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s43032-021-00586-3
  • Dergi Adı: REPRODUCTIVE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, MEDLINE
  • Sayfa Sayıları: ss.2610-2622
  • Anahtar Kelimeler: Estrogen receptor, Progesterone receptor, Endometritis, Resveratrol, GENE COPY NUMBER, ALPHA ER-ALPHA, CLINICAL ENDOMETRITIS, PROTEIN EXPRESSION, DAIRY-COWS, UTERINE, INFLAMMATION, HEALTH, GROWTH, CELLS
  • Gazi Üniversitesi Adresli: Evet

Özet

Endometritis is characterized by inflammation of the endometrial lining that leads to reduced reproductive potential. Restoring the impaired hormonal balance is an important component of endometritis treatment. The purpose of the current study was to evaluate the effects of resveratrol on estrogen and progesterone hormone status in endometritis. Mature female Sprague Dawley rats were used, and endometritis was induced by intrauterine infusion of Escherichia coli. Animals were treated with resveratrol alone or combined with marbofloxacin. Compared to the non-treated endometritis group, resveratrol treatment reduced serum oestradiol levels, increased serum progesterone levels, enhanced estrogen receptor (ER) expression in the uterine stroma, decreased ESR1 gene expression, and raised ESR2 gene expression. Resveratrol administration combined with marbofloxacin also increased ER expression in the uterine gland and progesterone receptor expression in the uterine epithelium. The findings of this study suggest that the actions of resveratrol on progesterone levels and estrogen receptor expression might be responsible for its beneficial effect in rats with endometritis.