Association of vitamin D receptor polymorphisms with vitamin D and calcium levels in Turkish multiple sclerosis patients

ELKAMA A., Orhan G., KARAHALİL B.

NEURODEGENERATIVE DISEASE MANAGEMENT, cilt.12, sa.6, ss.323-331, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2217/nmt-2022-0005
  • Dergi Adı: NEURODEGENERATIVE DISEASE MANAGEMENT
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.323-331
  • Anahtar Kelimeler: calcium, ELISA, multiple sclerosis, PCR-RFLP, vitamin D, vitamin D receptor polymorphisms, VDR GENE POLYMORPHISMS, D METABOLISM, RISK
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim: The present study was conducted to assess the impact of gene (vitamin D receptor [VDR] polymorphisms) - environment (serum vitamin D and calcium levels) interaction on multiple sclerosis (MS) risk. Materials & methods: FokI, BsmI, TaqI and ApaI genotyping were performed in 149 MS patients and 127 controls. We measured serum vitamin D and calcium levels. Results: No significant difference between VDR polymorphisms and MS risk was detected. In patients with FokI ff, BsmI Bb, TaqI Tt and ApaI AA genotypes, vitamin D levels were statistically higher. Serum calcium levels were significantly lower in patients with FokI FF, Ff, all BsmI and TaqI genotypes and ApaI AA and Aa genotypes. Conclusion: No significant association was found between VDR polymorphisms with MS risk.