Association of vitamin D receptor polymorphisms with vitamin D and calcium levels in Turkish multiple sclerosis patients

ELKAMA A., Orhan G., KARAHALİL B.

NEURODEGENERATIVE DISEASE MANAGEMENT, vol.12, no.6, pp.323-331, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.2217/nmt-2022-0005
  • Journal Name: NEURODEGENERATIVE DISEASE MANAGEMENT
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.323-331
  • Keywords: calcium, ELISA, multiple sclerosis, PCR-RFLP, vitamin D, vitamin D receptor polymorphisms, VDR GENE POLYMORPHISMS, D METABOLISM, RISK
  • Gazi University Affiliated: Yes

Abstract

Aim: The present study was conducted to assess the impact of gene (vitamin D receptor [VDR] polymorphisms) - environment (serum vitamin D and calcium levels) interaction on multiple sclerosis (MS) risk. Materials & methods: FokI, BsmI, TaqI and ApaI genotyping were performed in 149 MS patients and 127 controls. We measured serum vitamin D and calcium levels. Results: No significant difference between VDR polymorphisms and MS risk was detected. In patients with FokI ff, BsmI Bb, TaqI Tt and ApaI AA genotypes, vitamin D levels were statistically higher. Serum calcium levels were significantly lower in patients with FokI FF, Ff, all BsmI and TaqI genotypes and ApaI AA and Aa genotypes. Conclusion: No significant association was found between VDR polymorphisms with MS risk.