Differential pulse polarographic determination of Co(II) using moxifloxacine


Inam R. , Mercan H., Yilmaz E., Uslu B.

JOURNAL OF ANALYTICAL CHEMISTRY, cilt.62, sa.6, ss.592-598, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 62 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1134/s1061934807060172
  • Dergi Adı: JOURNAL OF ANALYTICAL CHEMISTRY
  • Sayfa Sayıları: ss.592-598

Özet

The polarographic reduction of Co(II) in the presence of moxifloxacin (1-cyclopropyl-7-[(S,S)-2.8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1.4-dihydro-4-oxo-3-quinolinecarboxylic acid) gives rise to an additional adsorption peak corresponding to the reduction of Co(II)-moxifloxacin complex on the mercury drop electrode at -1.17 V. This new peak is applicable to Co(II) determination with the linearity proportional to the Co(II) concentration in the range of 4.93 x 10(-7) -6.90 x 10(-5) M and can be attributed to an adsorption-controlled process with an irreversible reduction. Without using moxifloxacin, the polarographic determination of 2.50 x 10(-6) M Co(II) is impossible under the given conditions due to very poor sensitivity at -1.38 V. The proposed method showed good precision and accuracy with a relative standard deviation of 3.01% and relative error of +6.40% for the determination of 2.50 x 10(-6) M Co(II) next to 5.0 x 10(-6) M of Zn(II), Ni(II), and Cd(II). The accuracy of the method was also checked by the determination of Co(II) spiked with tap water and certified sea water, and the percentage recoveries were 97.5 and 96.7%, respectively (n = 4 at 95% confidence interval).