Liver immunology and herbal treatment


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BALABAN H. Y., Aka C., KOCA ÇALIŞKAN U.

WORLD JOURNAL OF HEPATOLOGY, vol.9, no.17, pp.757-770, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 17
  • Publication Date: 2017
  • Doi Number: 10.4254/wjh.v9.i17.757
  • Journal Name: WORLD JOURNAL OF HEPATOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.757-770
  • Keywords: Herbal treatments, Hepatic immunology, Drug induced liver injury, Adaptive immunity, Innate immunity, ZINGIBER-OFFICINALE-ROSCOE, MALVA-SYLVESTRIS L., THISTLE SILYBUM-MARIANUM, CASSIA-OCCIDENTALIS L., IN-VITRO ANTIOXIDANT, CARBON-TETRACHLORIDE, IMMUNOMODULATORY ACTIVITY, RAPHANUS-SATIVUS, ROSMARINUS-OFFICINALIS, CURRENT PERSPECTIVES
  • Gazi University Affiliated: Yes

Abstract

Beyond the metabolic functions, the liver recently has been defined as an organ of immune system (IS), which have central regulatory role for innate and adaptive immunity. The liver keeps a delicate balance between hepatic screening of pathogenic antigens and immune tolerance to self-antigens. Herbal treatments with immunological effects have potential to alter this hepatic immune balance towards either therapeutic side or diseases side by inducing liver injury via hepatotoxicity or initiation of autoimmune diseases. Most commonly known herbal treatments, which have therapeutic effect on liver and IS, have proven via in vitro, in vivo, and/or clinical studies were summarized in this review.