Neonatal multiple sulfatase deficiency with a novel mutation and review of the literature


NUR B., MIHÇI E., Pepe S., BİBEROĞLU G. , EZGÜ F. S. , Ballabio A., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.56, no.4, pp.418-422, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 4
  • Publication Date: 2014
  • Title of Journal : TURKISH JOURNAL OF PEDIATRICS
  • Page Numbers: pp.418-422

Abstract

Multiple sulfatase deficiency is a rare autosomal recessive disorder in which affected individuals present a complex phenotype due to the impaired activity of all sulfatases. There are different types of multiple sulfatase deficiency; among them, the neonatal form is the most severe, with a broad range of mucopolysaccharidosis-like symptoms and death within the first year of life. The disorder is caused by homozygous or compound heterozygous mutations in the sulfatase-modifying factor-1 (SUMF1) gene. In this article, we describe a non-ichthyotic neonatal multiple sulfatase deficiency patient with a novel mutation in the SUMF1 gene. The missense mutation c.777C>G, for which the patient was homozygous, had been caused by a p.N259K amino acid substitution. We evaluated the patient using clinical findings, neuroimaging studies and molecular analysis via the literature; we also wanted to note the difficulties in the diagnosis of this rare disease.