THE EFFECT OF EGB-761 ON RETINAL LIPID-PEROXIDATION AND GLUTATHIONE-PEROXIDASE LEVEL IN EXPERIMENTAL LENS-INDUCED UVEITIS

BILGIHAN A., ARICIOGLU A., BILGIHAN K., ONOL M., HASANREISOGLU B., TURKOZKAN N.

INTERNATIONAL OPHTHALMOLOGY, cilt.18, sa.1, ss.21-24, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1007/bf00919409
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.21-24
  • Gazi Üniversitesi Adresli: Evet

Özet

An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.