THE EFFECT OF EGB-761 ON RETINAL LIPID-PEROXIDATION AND GLUTATHIONE-PEROXIDASE LEVEL IN EXPERIMENTAL LENS-INDUCED UVEITIS


BILGIHAN A., ARICIOGLU A., BILGIHAN K., ONOL M., HASANREISOGLU B., TURKOZKAN N.

INTERNATIONAL OPHTHALMOLOGY, vol.18, no.1, pp.21-24, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 1994
  • Doi Number: 10.1007/bf00919409
  • Title of Journal : INTERNATIONAL OPHTHALMOLOGY
  • Page Numbers: pp.21-24

Abstract

An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.