Akademik Veri Yönetim Sistemi
NIGERIAN JOURNAL OF CLINICAL PRACTICE, cilt.25, sa.9, ss.1548-1556, 2022 (SCI-Expanded)
Background: Despite its extensive bone resorption and high recurrence
rate, marsupialization is the preferred option in the treatment of
odontogenic keratocysts (OKCs). Aim: We aimed to assess the effect of
marsupialization on histomorphological and biochemical markers of OKCs.
Materials and Methods: The study is conducted on 48 paraffin blocks of 24
OKC cases between the years 2012 to 2018. The main clinical, radiographic, and
histomorphometric measurements were recorded. Immunohistochemical staining
with E-cadherin, Ki67, IL1α, TNFα, Slug, and Snail were performed and compared
for pre-marsupialization and post-marsupialization values. Results: OKCs mostly
located in the mandibular posterior region. The mean marsupialization period was
8.8 ± 6.5 (3‑25) months. The mean radiographic size of OKC (57.1 ± 53.5 mm)
was significantly reduced after marsupialization (22.6 ± 19.9 mm, P = 0.002).
Histologically, significantly increased thickness of the OKC epithelium (p = 0.002)
and collagen production (p = 0.034) was detected after marsupialization. The
post‑marsupialization group showed positive correlation of inflammation score to
both TNFα (r: 0.69, P < 0.001) and IL-1α (r: 0.58, P = 0.008) expressions in
connective tissue. Among immunohistochemical parameters, only Slug expression
was significantly higher after marsupialization (p = 0.019). Conclusion: Our
study suggests that increased Slug expression may enable the second surgery by
increasing fibrosis in the cyst wall.
Keywords: EMT, keratocyst, marsupialization, slug, snail