Synthesis and antimicrobial activity of beta-[(2-benzimidazolyl)thio]-beta-benzoyl styrene derivatives

Ersan S., Nacak S., Acar N., Ozden T.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, cilt.47, sa.6, ss.773-775, 1997 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 1997
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.773-775
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study some new beta-[(2-benzimidazolyl)thio]-beta-benzoyl styrene derivatives have been synthesized by reacting 2-(phenacetylthio)benzimidazole and substituted benzaldehydes in piperidine / dry benzene. Structures were verified by microanalysis, IR and NMR spectral analysis. Antimicrobial activities of the compounds were investigated by the microdilution susceptibility test; Muller-Hinton Broth and Sabouraud Dextrose Broth were used for the determination of antibacterial and antifungal activity. Test organisms: Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as Gram (+) bacteria, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATTC 27853 as Gram (-) bacteria, and Candida albicans, Candida pseudotropicalis, Candida parapsilosis and Candida stellatoidea as yeast-like fungi. All the compounds showed good antimicrobial effect, especially against gram (+) bacteria. Among the compounds tested beta-[(2-benzimidazolyl)thio]-beta-benzoyl-4-chloro styrene (compound 9), beta-[(2-benzimidazolyl)thio]-beta-benzoyl-4-nitro styrene (compound 10) and beta-[(2-benzimidazolyl)thio]-beta-benzoyl-4-acetylamino styrene (compound 11) showed the most favorable activity.