With the lenghtening of the life expectation, the postmenopausel population is increasing and the life spent in postmenopausal years is about 1/3 of life. Estrogen has a lot of systemic effects; on skin, bone, cardiovascular system, brain, metabolic and almost all organ systems and tissues, especially on genitourinary. Generally has trophic and mitotic effect on tissues. Debrivation of estrogen in menopausel state potentiate aging proces, and cause some complaints. Substituition of estrogen can ameliorate almost all this abstienence symptomatology, but has some side effects to other organ systems beside of genital tract, sometimes to genital tract organs also. Estrogen improve life quality of the women. Because fear of some side effects it's endication restricted to only vazomotor symptomatologies of menopoz. Cardiovascular protection can not be as indication for estrogen replacement therapy. Before prescribing of estrogen preparation, patient should aveluated carefully systemically.