Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines

Geyik, Sirma; Ergun, Sercan; Kuzudisli, Samiye; Sensoy, Figen; Temiz, Ebru; Altunisik, Erman; Korkmaz, Murat; Dagli, HASAN; Kul, Seval; Akcali, Aylin; Neyal, Ayse

doi:10.1186/s10194-016-0623-z

Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines

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Geyik S., Ergun S., Kuzudisli S., Sensoy F., Temiz E., Altunisik E., ...More

JOURNAL OF HEADACHE AND PAIN, vol.17, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 17
Publication Date: 2016
Doi Number: 10.1186/s10194-016-0623-z
Journal Name: JOURNAL OF HEADACHE AND PAIN
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Gazi University Affiliated: No

Abstract

Background: Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms and genetics of migraine have not been fully clarified yet, but it is well-known that vascular changes considerably contribute in pathophysiology of migraine and also its complications. The aim of this study was to analyze the plasma U-II levels along with genotype distributions and allele frequencies for UTS2 Thr21Met and Ser89Asn polymorphisms among the patients with migraine without aura (MWoA).