Effects of the New Antifungal Thio Halo-Benzene Derivative 5-Bromo-2-Iodo-1,3-Bis(Phenylthio)Benzene Molecule on Rat Liver and Kidney Tissue Oxidative Events


Logoglu E. , ÇİNAR AVAR E. , COŞKUN CEVHER Ş.

GAZI UNIVERSITY JOURNAL OF SCIENCE, cilt.30, ss.237-244, 2017 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2017
  • Dergi Adı: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Sayfa Sayıları: ss.237-244

Özet

Nowadays, fluconazole is a widely used antifungal drug. Besides its similarities with the carbon structure of fluconazole, the newly synthesized 5-bromo-2-iodo-1,3-bis(phenylthio) benzene is also more active than low concentrated of fluconazole. Oxidative events occur in the organism during the drug metabolism. In this study, effects of previously proved as an antibacterial and antifungal molecule 5-bromo-2-iodo-1,3-bis(phenylthio) benzene investigated (C18H12S2IBr) on mammal liver and kidney tissue using biochemical methods. 80 male and female Wistar albino rats between the ranges of 150-200 gr have been used for this study. Kidney and liver tissues malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels, and myeloperoxidase activities (MPO) studied using spectrophotometric methods. We found that this new compound as a potential alternative to fluconazole did not cause any lipid peroxidation in the liver tissue of female rats and in kidney tissue of male rat. This could be because of hormone (gonadal hormone) or metabolism differences of the sexes. It may be remarkable to note that 5-bromo-2-iodo-1,3bis(phenylthio)benzene molecule does not cause nitrosative species formation at both doses and sexes. Also 5-bromo-2-iodo-1,3-bis(phenylthio)benzene may increase tissue antioxidant capacity in rats. Both doses of the newly synthesized 5-bromo-2-iodo-1,3-bis(phenylthio)benzene molecule may not cause respiratory burst in the liver and kidney tissues in both sexes.