Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis

Ozdogan M., Ersoy E., Dundar K., Albayrak L., Devay S., Gundogdu H.

JOURNAL OF SURGICAL RESEARCH, vol.129, no.2, pp.260-264, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 129 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2005.06.036
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.260-264

Abstract

Background. Underlying hepatic injury and cirrhosis are leading factors that interfere with the postoperative liver regeneration and function. Hyperbaric oxygenation (HBO) has been reported to ameliorate the ischemia-reperfusion injury of the liver, to induce compensatory hypertrophy of the predicted remnant liver in rats after portal vein ligation and to augment liver regeneration after hepatectomy in non-cirrhotic rats. Our aim was to determine the effect of HBO treatment on liver regeneration after partial hepatectomy in normal and cirrhotic mice in this experimental study.