The group emotional status of college students in public crisis events and the psychological warning mechanism of such derivative events have become an essential field of academic research in the epidemic era. In this paper, the era of the group in the outbreak of mental state as the research target, constructing the Family Environment, Social Satisfaction, Concerns of the Epidemic, Depression and Anxiety under the five dimensions of measurement indicators, using structural equation model (SEM) analysis of the special events under the background of the group in the influence of social factors. The results showed that four dimensions significantly impacted college students' social interaction against the epidemic. There was a negative correlation between family environment, concerning of the epidemic, and a positive correlation between depression and anxiety (path coefficients were 0.14, -0.05, 0.28 and 0.24, respectively). The contribution of this paper scientifically verifies the influence of social factors, and makes more rigorous and reasonable predictions for college students, moreover, it constructs an early warning and assisted decision-making mechanism for social interaction adapted to college students' resistance to the epidemic. It also provides a valuable theoretical basis for conducting in-depth research as well as a practical reference for the psychological education of college students in the context of the epidemic outbreak era.