Effects of Ketorolac on Colorectal Anastomosis in Rats

Basceken S. I., Okudur N. O., Tantoglu U., Dokcu S., Tikici D., Ohri N., ...Daha Fazla

REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS, cilt.36, sa.3, 2026 (SCI-Expanded, Scopus)

Özet

Despite being a significant cause of morbidity and mortality, colorectal anastomoses are an indisputable gastrointestinal system reconstruction surgery routine. Many patient-and disease-specific factors, including surgical technique, affect anastomotic healing. This study discusses the effects of ketorolac, used for analgesia after colorectal surgery, on the continuity of colorectal anastomoses and intraabdominal adhesions in a rat model. A prospective randomized study was performed at Laboratory of Experimental Animals and Research in the Institute. Thirty Wistar Albino rats were randomized into three equal groups, each consisting of 10 rats. Following rectal transection, end-to-end colorectal anastomosis was performed. During the postoperative period, animals received intramuscular injections of 10 mg/kg isotonic saline, 20 mg/kg meperidine, and 1 mg/kg ketorolac. On the postoperative day seven, the anastomotic segment was resected, and the Nair Score, anastomotic burst pressure, and OH-Proline levels were compared. The OH-Proline values were not statistically significant between the groups (P = 0.566). There was no statistically significant difference between the groups in terms of Nair Scores (P = 0.118). The anastomotic burst pressures of the groups were statistically significantly different (P = 0.017). The anastomotic burst pressures in the group receiving ketorolac were statistically significantly higher than the group receiving meperidine (P = 0.020). In conclusion, this study did not associate perioperative use of ketorolac with anastomotic leakage in the rat model.