The evaluation of bone metabolism in children with renal transplantation

BÜYÜKKARAGÖZ B., BAKKALOĞLU EZGÜ S. A., Kandur Y., Isiyel E., Akcaboy M., BUYAN N., ...Daha Fazla

PEDIATRIC TRANSPLANTATION, cilt.19, sa.4, ss.351-357, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/petr.12469
  • Dergi Adı: PEDIATRIC TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-357
  • Gazi Üniversitesi Adresli: Evet

Özet

This study aims to evaluate BMD and bone biomarkers and to investigate the effects of immunosuppressives on bone disease after RTx. Thirty-three RTR aged 16.7 +/- 3.7yr and healthy controls (n=32) were enrolled. There was no difference between pre-RTx BMD and BMD at the time of study (45.9 +/- 30.9months after RTx), while both values were lower than controls (p<0.01 and p<0.05, respectively). Worst BMD scores were obtained at sixth month after RTx (-0.2 +/- 0.9) and best at fourth year (1.4 +/- 1.3). 25-hydroxy-(OH) vitamin D and OPG were higher in RTR (p<0.001). BMD z scores negatively correlated with OPG and cumulative CS doses at the time of study (r=-0.344, p<0.05 and r=-0.371, p<0.05, respectively). Regression analysis revealed OPG as the only predictor of BMD ( -0.78, 95% CI -0.004 to -0.013, p<0.001). The increase in OPG, a significant predictor of BMD, could either be secondary to graft dysfunction or for protection against bone loss. CS doses should be minimized to avoid their untoward effects on bone metabolism.